By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Nanoparticles. According to news reporting out of Brussels, Belgium, by NewsRx editors, research stated, "Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes."
Our news journalists obtained a quote from the research from the Catholic University of Louvain, "Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days."
According to the news editors, the research concluded: "We demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds."
For more information on this research see: Combined effect of PLGA and curcumin on wound healing activity. Journal of Controlled Release, 2013;171(2):208-215. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
Our news journalists report that additional information may be obtained by contacting K.K. Chereddy, Catholic University of Louvain, Louvain Drug Res Inst, B-1200 Brussels, Belgium. Additional authors for this research include R. Coco, P.B. Memvanga, B. Ucakar, A. des Rieux, G. Vandermeulen and V. Preat (see also Nanoparticles).
Keywords for this news article include: Europe, Belgium, Brussels, Nanotechnology, Emerging Technologies
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