By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Amino Acids have been published. According to news reporting from Washington, District of Columbia, by NewsRx journalists, research stated, "To understand which organic molecules are capable of binding to gold nanoparticles and/or inducing nanoparticle aggregation, we investigate the interaction of gold nanoparticles with small molecules and amino acids at variable pH. Dynamic Light Scattering (DLS) and ultraviolet-visible (UV-vis) spectra were measured on mixtures of colloidal gold with small molecules to track the progression of the aggregation of gold nanoparticles."
The news correspondents obtained a quote from the research from George Washington University, "We introduce the 522 to 435 nm UV-vis absorbance ratio as a sensitive method for the detection of colloidal gold aggregation, whereby we delineate the ability of thiol, amine, and carboxylic acid functional groups to bind to the surfaces of gold nanoparticles and investigate how combinations of these functional groups affect colloidal stability. We present models for mechanisms of aggregation of colloidal gold, including surface charge reduction and bridging linkers. For all molecules whose addition leads to the aggregation of gold nanoparticles, the aggregation kinetics were accelerated at acidic pH values. Colloidal gold is maintained only in the presence of anionic carboxyl groups, which are neutralized by protonation at lower pH."
According to the news reporters, the research concluded: "The overall reduced charge on the stabilizing carboxyl groups accounts for the accelerated aggregation at lower pH values."
For more information on this research see: Small molecule- and amino acid-induced aggregation of gold nanoparticles. Langmuir, 2013;29(25):7661-73. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
Our news journalists report that additional information may be obtained by contacting H.M. Zakaria, Dept. of Physics, The George Washington University, Washington, DC 20052, United States. Additional authors for this research include A. Shah, M. Konieczny, J.A. Hoffmann, A.J. Nijdam and M.E Reeves (see also Amino Acids).
Keywords for this news article include: Peptides, Proteins, Washington, Amino Acids, Nanoparticle, United States, Nanotechnology, District of Columbia, Emerging Technologies, North and Central America.
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