By a News Reporter-Staff News Editor at Diabetes Week -- Investigators publish new report on Nanoporous. According to news reporting from Storrs, Connecticut, by NewsRx journalists, research stated, "Needle-implantable sensors have shown to provide reliable continuous glucose monitoring for diabetes management. In order to reduce tissue injury during sensor implantation, there is a constant need for device size reduction, which imposes challenges in terms of sensitivity and reliability, as part of decreasing signal-to-noise and increasing layer complexity."
The news correspondents obtained a quote from the research from the University of Connecticut, "Herein, we report sensitivity enhancement via electrochemical surface rebuilding of the working electrode (WE), which creates a three-dimensional nanoporous configuration with increased surface area. The gold WE was electrochemically rebuilt to render its surface nanoporous followed by decoration with platinum nanoparticles. The efficacy of such process was studied using sensor sensitivity against hydrogen peroxide (H2O2). For glucose detection, the WE was further coated with five layers, namely, (1) polyphenol, (2) glucose oxidase, (3) polyurethane, (4) catalase, and (5) dexamethasone-releasing poly(vinyl alcohol)/poly(lactic-co-glycolic acid) composite. The amperometric response of the glucose sensor was noted in vitro and in vivo. Scanning electron microscopy revealed that electrochemical rebuilding of the WE produced a nanoporous morphology that resulted in a 20-fold enhancement in H2O2 sensitivity, while retaining >98% selectivity. This afforded a 4-5-fold increase in overall glucose response of the glucose sensor when compared with a control sensor with no surface rebuilding and fittable only within an 18 G needle. The sensor was able to reproducibly track in vivo glycemic events, despite the large background currents typically encountered during animal testing. Enhanced sensor performance in terms of sensitivity and large signal-to-noise ratio has been attained via electrochemical rebuilding of the WE."
According to the news reporters, the research concluded: "This approach also bypasses the need for conventional and nanostructured mediators currently employed to enhance sensor performance."
For more information on this research see: Enhancing the sensitivity of needle-implantable electrochemical glucose sensors via surface rebuilding. Journal of Diabetes Science and Technology, 2013;7(2):441-51 (see also Nanoporous).
Our news journalists report that additional information may be obtained by contacting S. Vaddiraju, Biorasis Inc Technology Incubation Program, University of Connecticut, Storrs, CT 06269, United States. Additional authors for this research include A. Legassey, L. Qiang, Y. Wang, D.J. Burgess and F. Papadimitrakopoulos.
Keywords for this news article include: Storrs, Chemistry, Nanoporous, Connecticut, United States, Nanotechnology, Electrochemical, Emerging Technologies, North and Central America.
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