By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting originating from Kwangju, South Korea, by NewsRx correspondents, research stated, "A dual-function nano-system for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) was constructed. Gold nanorods (GNRs) as a PTT agent and chlorin e6 (Ce6) as a photosensitizer (PS) for PDT were loaded into a chitosan-functionalized, Pluronic-based nanogel that was proven to be an efficient delivery vehicle to the tumor site in vivo."
Our news editors obtained a quote from the research from the School of Materials Science and Engineering, "Previously reported combined therapy systems relied on quenching and de-quenching of PS for PDT upon thermo-impact of PTT, thus only PTT followed by PDT procedure was possible. In contrast, the present dual-acting system has no quenching between PS and GNRs by preventing direct contact and self-aggregation of photo-sensitizers, allowing independent PDT or PTT procedure. In both in vitro cell culture and in vivo tumor-bearing mice experiments, a remarkably enhanced tumor ablation compared to the treatment of PDT or PTT only was observed by the treatment of PDT followed by PTT, but not significantly by the treatment of PTT followed by PDT."
According to the news editors, the research concluded: "Thus, the present study demonstrated the synergistic effect of PDT and PTT in a sequence-dependent manner, and our system is a promising dual function nano system to achieve the enhanced phototherapy in vivo."
For more information on this research see: Tumor-targeting nanogel that can function independently for both photodynamic and photothermal therapy and its synergy from the procedure of PDT followed by PTT. Journal of Controlled Release, 2013;171(2):113-121. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news editors report that additional information may be obtained by contacting J.Y. Kim, Gwangju Inst Sci & Technol, Sch Mat Sci & Engn, Kwangju 500712, South Korea. Additional authors for this research include W.I. Choi, M. Kim and G. Tae (see also Drugs and Therapies).
Keywords for this news article include: Asia, Kwangju, Treatment, South Korea, Drugs and Therapies
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