By a News Reporter-Staff News Editor at Drug Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting from Mashhad, Iran, by NewsRx journalists, research stated, "In the present work a series of imprinted (MIPs) and non-imprinted (NIPs) hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA) as a backbone monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker monomer, methacrylic acid (MAA) as a functional monomer and dorzolamide (DZD) as the template molecule. Different concentrations of MAA (0, 100, 200, 400 mM) were used for preparation of NIPs."
The news correspondents obtained a quote from the research from the Mashhad University of Medical Sciences, "Two DZD: MAA molar ratios (1:8 and 1:4) and 400 mM MAA were also applied in imprinting process. The hydrogels (0.4 mm thickness) were synthesized by thermal polymerization at 50°C in 24h in a polypropylene mould. Then, the swelling and binding properties of hydrogels were evaluated in water. Their loading and releasing properties were also studied in NaCl 0.9% and artificial lachrymal fluid. The results showed that using MAA as co-monomer and applying molecular imprinting technique increased loading capacity of hydrogels. The optimized imprinted hydrogel (MIP1:4), prepared with 400 mM MAA and DZD: MAA molar ratio of 1:4, had the highest affinity for DZD and the greatest ability to control the release process in aqueous media."
According to the news reporters, the research concluded: "Our data indicated that the use of suitable co-monomer and applying a molecular imprinting technique had important influence on loading and releasing properties of hydrogels."
For more information on this research see: Preparation of a molecularly imprinted soft contact lens as a new ocular drug delivery system for dorzolamide. Current Drug Delivery, 2013;10(3):279-85. (Bentham Science Publishers - www.benthamscience.com; Current Drug Delivery - www.benthamscience.com/cdd/index.htm)
Our news journalists report that additional information may be obtained by contacting B. Malaekeh-Nikouei, Nanotechnology Research Centre, School of pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Additional authors for this research include S.A. Vahabzadeh and S.A Mohajeri (see also Drugs and Therapies).
Keywords for this news article include: Iran, Asia, Mashhad, Drugs and Therapies.
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