By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Inflammation. According to news originating from Kumamoto, Japan, by NewsRx correspondents, research stated, "Transdermal delivery is a useful and attractive method for drug delivery, even though the stratum corneum is a major barrier of protein translocation into the skin. To achieve protein delivery through the stratum corneum, we first cast gold nanorods, acting as a heating device in response to near-infrared light irradiation, onto the skin surface."
Our news journalists obtained a quote from the research from Kumamoto University, "After applying an aqueous solution of ovalbumin to the skin, the skin was irradiated by near-infrared laser light. Irradiation of the skin using a continuous-wave laser increased the skin temperature resulting in an efficient translocation of ovalbumin into the skin. Furthermore, migration of inflammation cells and induction heat shock protein 70 (HSP70) were observed. Irradiation of the skin using a pulsed laser caused an enhanced permeability of the stratum corneum without an increase in skin temperature, migration of inflammation cells, or HSP70 induction. This effect is due to the pulsed-laser irradiation increasing the temperature of a limited part of the skin surface. Thus, the physiological response of skin is dependent on the type of laser light used."
According to the news editors, the research concluded: "It is anticipated that this phenomenon will find wide application in such applications as, for example, general transdermal protein delivery and transdermal vaccination."
For more information on this research see: CW/pulsed NIR irradiation of gold nanorods: Effect on transdermal protein delivery mediated by photothermal ablation. Journal of Controlled Release, 2013;171(2):178-183. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news correspondents report that additional information may be obtained from H. Tang, Kumamoto University, Grad Sch Sci & Technol, Dept. of Appl Chem & Biochem, Chuo Ku, Kumamoto 8608555, Japan. Additional authors for this research include H. Kobayashi, Y. Niidome, T. Mori, Y. Katayama and T. Niidome (see also Inflammation).
Keywords for this news article include: Asia, Japan, Kumamoto, Inflammation
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