The news correspondents obtained a quote from the research, "Results in humans undergoing gene transfer indicate that capsid-specific T cell responses directed against transduced cells may limit the duration of transgene expression following AAV gene transfer, and similarly anti-AAV neutralizing antibodies can completely prevent transduction of a target tissue, resulting in lack of efficacy. Anti-AAV neutralizing antibodies are highly prevalent in humans, and the frequency of subjects with detectable titers can reach up to two thirds of the population. The approach to the problem of preexisting humoral immunity to AAV so far has been the exclusion of seropositive subjects, but this solution is far from being optimal. Several additional strategies have been proposed and tested in a variety of preclinical animal models. Future studies will help defining the optimal strategy, or combination of strategies, to successfully treat subjects with preexisting antibodies to AAV due to natural infection or to prior administration of AAV vectors."
According to the news reporters, the research concluded: "These advancements will likely have a significant impact on the field of gene transfer with AAV vectors."
For more information on this research see: Humoral immunity to AAV vectors in gene therapy: challenges and potential solutions. Discovery Medicine, 2013;15(85):379-89 (see also technology.html">Biotechnology).
Our news journalists report that additional information may be obtained by contacting
Keywords for this news article include: Biotechnology,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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