By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Nephrology is the subject of a report. According to news reporting originating from Indianapolis, Indiana, by NewsRx correspondents, research stated, "Focused ultrasound has the potential to expel small stones or residual stone fragments from the kidney, or move obstructing stones to a nonobstructing location. We evaluated the efficacy and safety of ultrasonic propulsion in a live porcine model."
Our news editors obtained a quote from the research from Indiana University, "Calcium oxalate monohydrate kidney stones and laboratory model stones (2 to 8 mm) were ureteroscopically implanted in the renal pelvicalyceal system of 12 kidneys in a total of 8 domestic swine. Transcutaneous ultrasonic propulsion was performed using an HDI C5-2 imaging transducer (ATL/Philips, Bothell, Washington) and the Verasonics ® diagnostic ultrasound platform. Successful stone relocation was defined as stone movement from the calyx to the renal pelvis, ureteropelvic junction or proximal ureter. Efficacy and procedure time was determined. Three blinded experts evaluated histological injury to the kidney in the control, sham treatment and treatment arms. All 26 stones were observed to move during treatment and 17 (65%) were relocated successfully to the renal pelvis (3), ureteropelvic junction (2) or ureter (12). Average +/- SD successful procedure time was 14 +/- 8 minutes and a mean of 23 +/- 16 ultrasound bursts, each about 1 second in duration, were required. There was no evidence of gross or histological injury to the renal parenchyma in kidneys exposed to 20 bursts (1 second in duration at 33-second intervals) at the same output (2,400 W/cm(2)) used to push stones. Noninvasive transcutaneous ultrasonic propulsion is a safe, effective and time efficient means to relocate calyceal stones to the renal pelvis, ureteropelvic junction or ureter."
According to the news editors, the research concluded: "This technology holds promise as a useful adjunct to surgical management for renal calculi."
For more information on this research see: Focused Ultrasound to Expel Calculi from the Kidney: Safety and Efficacy of a Clinical Prototype Device. Journal of Urology, 2013;190(3):1090-1095. Journal of Urology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Journal of Urology - www.elsevier.com/wps/product/cws_home/706695)
The news editors report that additional information may be obtained by contacting J.D. Harper, Indiana University, Sch Med, Dept. of Anat & Cell Biol, Indianapolis, IN, United States. Additional authors for this research include M.D. Sorensen, B.W. Cunitz, Y.N. Wang, J.C. Simon, F. Starr, M. Paun, B. Dunmire, H.D. Liggitt, A.P. Evan, J.A. McAteer, R.S. Hsi and M.R. Bailey (see also Nephrology).
Keywords for this news article include: Kidney, Calculi, Treatment, Nephrology, Indianapolis, United States, North and Central America
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