By a News Reporter-Staff News Editor at Biotech Business Week -- Current study results on Genomics have been published. According to news reporting from New Haven, Connecticut, by NewsRx journalists, research stated, "The numerous classes of repeats often impede the assembly of genome sequences from the short reads provided by new sequencing technologies. We demonstrate a simple and rapid means to ascertain the repeat structure and total size of a bacterial or archaeal genome without the need for assembly by directly analyzing the abundances of distinct k-mers among reads."
The news correspondents obtained a quote from the research from Yale University, "The sensitivity of this procedure to resolve variation within a bacterial species is demonstrated: genome sizes and repeat structure of five environmental strains of E. coli from short Illumina reads were estimated by this method, and total genome sizes corresponded well with those obtained for the same strains by pulsed-field gel electrophoresis. In addition, this approach was applied to read-sets for completed genomes and shown to be accurate over a wide range of microbial genome sizes. Application of these procedures, based solely on k-mer abundances in short read data sets, allows aspects of genome structure to be resolved that are not apparent from conventional short read assemblies."
According to the news reporters, the research concluded: "This knowledge of the repetitive content of genomes provides insights into genome evolution and diversity."
For more information on this research see: Rapid quantification of sequence repeats to resolve the size, structure and contents of bacterial genomes. Bmc Genomics, 2013;14():537. (BioMed Central - www.biomedcentral.com/; Bmc Genomics - www.biomedcentral.com/bmcgenomics/)
Our news journalists report that additional information may be obtained by contacting D. Williams, Dept. of Ecology & Evolutionary Biology, Yale University, New Haven, Connecticut 06520, United States. Additional authors for this research include W.L. Trimble, M. Shilts, F. Meyer and H. Ochman (see also Genomics).
Keywords for this news article include: Genomics, New Haven, Connecticut, United States, Bacterial Genome, North and Central America.
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