By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Investigators publish new report on Angiogenesis. According to news reporting out of Baltimore, Maryland, by NewsRx editors, research stated, "The evolution in our understanding of tumor angiogenesis has been the result of pioneering imaging and computational modeling studies spanning the endothelial cell, microvasculature and tissue levels. Many of these primary data on the tumor vasculature are in the form of images from pre-clinical tumor models that provide a wealth of qualitative and quantitative information in many dimensions and across different spatial scales."
Our news journalists obtained a quote from the research from the Johns Hopkins University School of Medicine, "However, until recently, the visualization of changes in the tumor vasculature across spatial scales remained a challenge due to a lack of techniques for integrating micro-and macroscopic imaging data. Furthermore, the paucity of three-dimensional (3-D) tumor vascular data in conjunction with the challenges in obtaining such data from patients presents a serious hurdle for the development and validation of predictive, multiscale computational models of tumor angiogenesis. In this review, we discuss the development of multiscale models of tumor angiogenesis, new imaging techniques capable of reproducing the 3-D tumor vascular architecture with high fidelity, and the emergence of 'image-based models' of tumor blood flow and molecular transport. Collectively, these developments are helping us gain a fundamental understanding of the cellular and molecular regulation of tumor angiogenesis that will benefit the development of new cancer therapies."
According to the news editors, the research concluded: "Eventually, we expect this exciting integration of multiscale imaging and mathematical modeling to have widespread application beyond the tumor vasculature to other diseases involving a pathological vasculature, such as stroke and spinal cord injury."
For more information on this research see: Multiscale imaging and computational modeling of blood flow in the tumor vasculature. Annals of Biomedical Engineering, 2012;40(11):2425-41. Annals of Biomedical Engineering can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Annals of Biomedical Engineering - www.springerlink.com/content/0090-6964/)
Our news journalists report that additional information may be obtained by contacting E. Kim, Dept. of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Additional authors for this research include S. Stamatelos, J. Cebulla, Z.M. Bhujwalla, A.S. Popel and A.P Pathak (see also Angiogenesis).
Publisher contact information for the journal Annals of Biomedical Engineering is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Maryland, Baltimore, Angiogenesis, United States, North and Central America.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC