By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Digestive System Diseases and Conditions are discussed in a new report. According to news reporting from Wuhan, People's Republic of China, by NewsRx journalists, research stated, "This study aimed to provide new insights into the mechanisms of hepatocellular carcinoma (HCC) invasion by simultaneously imaging tumor cells and major components of the tumor microenvironment. Formalin-fixed paraffin-embedded human HCC tissues were studied by conventional immunohistochemistry and quantum dot-based multiplexed imaging to reveal type IV collagen, LOX and tumor angiogenesis."
The news correspondents obtained a quote from the research from the Zhongnan Hospital of Wuhan University, "Type IV collagen degradation and repatterning in the extracellular matrix (ECM) was a continuous process, making the ECM harder, although more fragile and less resistant to cancer invasion. The distribution of LOX among cancer nests was heterogeneous, with higher expression in small cancer nests and lower expression in large cancer nests. LOX expression in cancer cells was associated with rigid stroma and tumor angiogenesis. Tumor angiogenesis occurred with type IV collagen presence. At the cancer invasion front, the ECM was hydrolyzed, with the prominent linear reorientation of type IV collagen surrounding cancer nests adjacent to neovessels."
According to the news reporters, the research concluded: "The visualization of the temporal-spatial relationship between type IV collagen, LOX and tumor angiogenesis revealed the coevolution process of HCC cells and their microenvironment, emphasizing an active role of the ECM during cancer invasion."
For more information on this research see: Coevolution of the tumor microenvironment revealed by quantum dot-based multiplexed imaging of hepatocellular carcinoma. Future Oncology, 2013;9(7):1029-37 (see also Digestive System Diseases and Conditions).
Our news journalists report that additional information may be obtained by contacting M. Fang, Dept. of Oncology, Zhongnan Hospital of Wuhan University & Hubei Key Laboratory of Tumor Biological Behaviors & Hubei Cancer Clinical Study Center, Number 169 Donghu Road, Wuchang District, Wuhan, 430071, People's Taiwan. Additional authors for this research include C.W. Peng, J.P. Yuan, Z.L. Zhang, D.W. Pang and Y. Li.
Keywords for this news article include: Asia, Wuhan, Cancer, Collagen, Oncology, Angiogenesis, Quantum Dots, Nanotechnology, Emerging Technologies, Hepatocellular Carcinoma, People's Republic of China, Extracellular Matrix Proteins, Digestive System Diseases and Conditions.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC