By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Epithelial Cells are presented in a new report. According to news reporting originating from Jackson, Mississippi, by NewsRx correspondents, research stated, "Quantum dots (QD) nanoparticles have been widely used in biomedical and electronics fields, because of their novel optical properties. Consequently it confers enormous potential for human exposure and environmental release."
Our news editors obtained a quote from the research from Jackson State University, "To increase the biocompatibility of QDs, a variety of surface coatings or functional groups are added to increase their bioactivity and water solubility. Human adult low calcium high temperature (HaCaT) cells are the epithelial cells derived from adult human skin that exhibits normal differentiation capacity and a DNA fingerprint pattern that is unaffected by long-term cultivation, transformation, or the presence of multiple chromosomal alternations. Human keratinocytes, HaCaT cells were used to systematically evaluate the cytotoxicity of biocompatible QD made of CdSe metal core and ZnS shell with three different coatings and at three different wavelengths (530, 580 and 620 nm). In terms of half-maximal inhibitory concentration, QSA-QDs with amine-polyethyleneglycol coating and QSH-QDs with amphiphilic polymer coating were not cytotoxic, while QEI-QDs with polyethylenimine coating were highly toxic to the HaCaT cells in comparison to a reference CuInS2/ZnS. QEI-QDs led to significant increase in reactive oxygen species, decrease in mitochondrial membrane potential and DNA damage in HaCaT cells. The mechanisms of toxicity of QEI-530 and QEI-580 can be attributed to the combination of intracellular reactive oxygen species production and loss of MMP."
According to the news editors, the research concluded: "The QDs toxicity can be attributed to the polyethylemimine surface coating which was highly toxic to cells in comparison with amine-polyethyleneglycol, but not due to the release of cadmium ions."
For more information on this research see: In vitro cytotoxicity of CdSe/ZnS quantum dots with different surface coatings to human keratinocytes HaCaT cells. Journal of Environmental Sciences, 2013;25(1):163-71. Journal of Environmental Sciences can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands. (Elsevier - www.elsevier.com; Journal of Environmental Sciences - www.elsevier.com/wps/product/cws_home/709941)
The news editors report that additional information may be obtained by contacting K. Pathakoti, Dept. of Biology, Jackson State University, Jackson, Mississippi 39217, United States. Additional authors for this research include H.M. Hwang, H. Xu, Z.P. Aguilar and A. Wang (see also Epithelial Cells).
Publisher contact information for the Journal of Environmental Sciences is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.
Keywords for this news article include: Jackson, Mississippi, Quantum Dots, United States, Keratinocytes, Nanotechnology, Quantum Physics, Epithelial Cells, Emerging Technologies, North and Central America.
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