By a News Reporter-Staff News Editor at Stem Cell Week -- Fresh data on Stem Cell Research are presented in a new report. According to news reporting from Piscataway, New Jersey, by NewsRx journalists, research stated, "Monitoring of stem cell differentiation and pluripotency is an important step for the practical use of stem cells in the field of regenerative medicine. Hence, a new non-destructive detection tool capable of in situ monitoring of stem cell differentiation is highly needed."
The news correspondents obtained a quote from the research from Rutgers State University, "In this study, we report a 3D graphene oxide-encapsulated gold nanoparticle that is very effective for the detection of the differentiation potential of neural stem cells (NSCs) based on surface-enhanced Raman spectroscopy (SERS). A new material, 3D GO-encapsulated gold nanoparticle, is developed to induce the double enhancement effect of graphene oxide and gold nanoparticle on SERS signals which is only effective for undifferentiated NSCs. The Raman peaks achieved from undifferentiated NSCs on the graphene oxide (GO)-encapsulated gold nanoparticles were 3.5 times higher than peaks obtained from normal metal structures and were clearly distinguishable from those of differentiated cells. The number of C=C bonds and the Raman intensity at 1656 cm(-1) was found to show a positive correlation, which matches the differentiation state of the NSCs. Moreover, the substrate composed of 3D GO-encapsulated gold nanoparticles was also effective at distinguishing the differentiation state of single NSC by using electrochemical and electrical techniques."
According to the news reporters, the research concluded: "Hence, the proposed technique can be used as a powerful non-destructive in situ monitoring tool for the identification of the differentiation potential of various kinds of stem cells (mesenchymal, hematopoietic, and neural stem cells)."
For more information on this research see: 3D graphene oxide-encapsulated gold nanoparticles to detect neural stem cell differentiation. Biomaterials, 2013;34(34):8660-8670. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting T.H. Kim, Rutgers State University, Dept. of Chem & Chem Biol, Piscataway, NJ 08854, United States. Additional authors for this research include K.B. Lee and J.W. Choi (see also Stem Cell Research).
Keywords for this news article include: Piscataway, New Jersey, United States, Nanotechnology, Gold Nanoparticles, Stem Cell Research, Cell Differentiation, Emerging Technologies, North and Central America
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