By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Investigators publish new report on Angiogenesis. According to news reporting from Hong Kong, People's Republic of China, by NewsRx journalists, research stated, "Cerium oxide nanoparticles (nanoceria) are widely reported to be non-cytotoxic and modulate intracellular reactive oxygen species (ROS). In this study, nanoceria (d(XRD) = 12 nm) were functionalised with either 130 or 880 molecules of unfractionated heparin using the organosilane linker, 3-aminopropyltriethoxysilane."
The news correspondents obtained a quote from the research from the City University of Hong Kong, "Nanoceria with a low level of heparin functionalisation were found to scavenge intracellular ROS to the same extent as unfunctionalised nanoceria and significantly more than cells exposed to medium only. In contrast, nanoceria with the highest level of heparin functionalisation were not as effective at scavenging intracellular ROS. Nanoceria were localised predominantly in the cytoplasm, while heparin-nanoceria were localised in both the cytoplasm and lysosomes. Together these data demonstrated that the level of nanoceria surface functionalisation with heparin determined the intracellular localisation and ROS scavenging ability of these particles."
According to the news reporters, the research concluded: "Additionally, heparin-nanoceria were effective in reducing endothelial cell proliferation indicating that they may find application in the control of angiogenesis in cancer in the future."
For more information on this research see: Anti-angiogenic activity of heparin functionalised cerium oxide nanoparticles. Biomaterials, 2013;34(34):8808-8818. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting M.S. Lord, City University of Hong Kong, Sch Energy & Environm, Clean Energy & Nanotechnol CLEAN Lab, Kowloon, Hong Kong, People's Republic of China. Additional authors for this research include B. Tsoi, C. Gunawan, W.Y. Teoh, R. Amal and J.M. Whitelock (see also Angiogenesis).
Keywords for this news article include: Asia, Hong Kong, Angiogenesis, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China
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