By a News Reporter-Staff News Editor at Cardiovascular Week -- Fresh data on Cardiovascular Research are presented in a new report. According to news reporting from Changchun, People's Republic of China, by NewsRx journalists, research stated, "The purpose of this work was to investigate the cardiovascular toxicity of different sizes and different dosages of silica nanoparticles in Wistar rats. The three silica nanoparticles (30, 60, and 90 nm) and one fine silica particles (600 nm) at three doses of 2, 5, and 10 (mg/Kg bw) were used in the present experiment."
The news correspondents obtained a quote from the research from Jilin University, "After intratracheal instillation for a total of 16 times, concentration of Si in hearts and serum was measured by inductively coupled plasma optical emission spectrometer. The hematology parameters were analyzed by an automated hematology analyzer, and the inflammatory reaction, oxidative stress, endothelial dysfunction, and the myocardial enzymes in serum were measured by kits. Our results showed intratracheal-instilled silica nanoparticles could pass through the alveolar-capillary barrier into systemic circulation. Concentration of Si in the heart and serum depended on the particles size and dosage. The levels of reactive oxygen species (ROS) at 5, 10 mg/Kg bw of the three silica nanoparticles were higher than the fine silica particles. Blood levels of inflammation-related high-sensitivity C-reactive protein and cytokines such as interleukin-1beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha were increased after exposure to three silica nanoparticles at 10 mg/Kg bw. Moreover, the levels of IL-1 beta and IL-6 at 10 mg/Kg bw of silica nanoparticles (30 nm) were higher than the fine silica particles. Significant decrease in superoxide dismutase, glutathione peroxidase and significant increase in malondialdehyde were observed at 10 mg/Kg bw of the three silica nanoparticles. A significant decrease in nitric oxide (NO) production was induced which coincided with the reduction of nitric oxide synthase (NOS) activity and the excessive generation of ROS in rats. The levels of intercellular adhesion molecule-l and vascular cell adhesion molecule-l elevated significantly after exposure to three silica nanoparticles at 10 mg/Kg bw, which are considered as early steps of endothelial dysfunction. We conclude that cardiovascular toxicity of silica nanoparticles could be related to the particles size and dosage. Oxidative stress could be involved in inflammatory reaction and endothelial dysfunction, all of which could aggravate cardiovascular toxicology."
According to the news reporters, the research concluded: "In addition, endothelial NO/NOS system disorder caused by nanoparticles could be one of the mechanisms for endothelial dysfunction."
For more information on this research see: Cardiovascular Toxicity of Different Sizes Amorphous Silica Nanoparticles in Rats After Intratracheal Instillation. Cardiovascular Toxicology, 2013;13(3):194-207. Cardiovascular Toxicology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Cardiovascular Toxicology - www.springerlink.com/content/1530-7905/)
Our news journalists report that additional information may be obtained by contacting Z.J. Du, Jilin University, China Japan Union Hosp, Resp Department, Changchun 130033, Jilin, People's Republic of China. Additional authors for this research include D.L. Zhao, L. Jing, G.Q. Cui, M.H. Jin, Y. Li, X.M. Liu, Y. Liu, H.Y. Du, C.X. Guo, X.Q. Zhou and Z.W. Sun (see also Cardiovascular Research).
Keywords for this news article include: Asia, Changchun, Chemicals, Chemistry, Cardiology, Nanoparticle, Nitric Oxide, Nanotechnology, Emerging Technologies, Cardiovascular Research, People's Republic of China
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