By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Enzymes and Coenzymes is now available. According to news reporting originating in Delft, Netherlands, by NewsRx journalists, research stated, "In this tutorial review, an overview of the why, what and how of enzyme immobilisation for use in biocatalysis is presented. The importance of biocatalysis in the context of green and sustainable chemicals manufacture is discussed and the necessity for immobilisation of enzymes as a key enabling technology for practical and commercial viability is emphasised."
The news reporters obtained a quote from the research from the Delft University of Technology, "The underlying reasons for immobilisation are the need to improve the stability and recyclability of the biocatalyst compared to the free enzyme. The lower risk of product contamination with enzyme residues and low or no allergenicity are further advantages of immobilised enzymes. Methods for immobilisation are divided into three categories: adsorption on a carrier (support), encapsulation in a carrier, and cross-linking (carrier-free). General considerations regarding immobilisation, regardless of the method used, are immobilisation yield, immobilisation efficiency, activity recovery, enzyme loading (wt% in the biocatalyst) and the physical properties, e.g. particle size and density, hydrophobicity and mechanical robustness of the immobilisate, i.e. the immobilised enzyme as a whole (enzyme + support). The choice of immobilisate is also strongly dependent on the reactor configuration used, e.g. stirred tank, fixed bed, fluidised bed, and the mode of downstream processing."
According to the news reporters, the research concluded: "Emphasis is placed on relatively recent developments, such as the use of novel supports such as mesoporous silicas, hydrogels, and smart polymers, and cross-linked enzyme aggregates (CLEAs)."
For more information on this research see: Enzyme immobilisation in biocatalysis: why, what and how. Chemical Society Reviews, 2013;42(15):6223-35. (Royal Society of Chemistry - www.rsc.org/; Chemical Society Reviews - pubs.rsc.org/en/journals/journalissues/cs)
Our news correspondents report that additional information may be obtained by contacting R.A. Sheldon, Dept. of Biotechnology, Delft University of Technology, Julianalaan 136, Delft 2628BL, Netherlands (see also Enzymes and Coenzymes).
Keywords for this news article include: Delft, Europe, Netherlands, Enzymes and Coenzymes.
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