By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Research findings on Small Interference RNAs (siRNAs) are discussed in a new report. According to news originating from Tours, France, by NewsRx correspondents, research stated, "Short interfering RNAs (siRNAs) can downregulate the synthesis of proteins and thus be used to treat certain diseases where the protein synthesis is upregulated, such as cancer. The challenge is to deliver siRNAs in the target cell as they are rapidly degraded by nucleases and have difficulties to cross the cellular membranes."
Our news journalists obtained a quote from the research from the University of Tours, "Superparamagnetic iron oxide nanoparticles (SPIONs) are widely studied as platforms for smart biocompatible nanosystems which can be used for magnetic drug targeting and magnetic resonance imaging. The aim of this work was to combine siRNAs, SPIONs, and chitosan, to develop new magnetic siRNA nanovectors suitable for systemic administration. In a first time, the one factor at a time (OFAT) methodology was used to adjust different formulation parameters and to test the feasibility of such a formulation. In a second time, design of experiment (DOE) methodology was used to analyze the influence of these formulation parameters on the physicochemical characteristics hydrodynamic diameter (DH)and zeta-potential. Finally, four MSNs suitable for systemic administration could be identified using the OFAT method."
According to the news editors, the research concluded: "The DOE method showed a significant effect of CR and [NaNO3] on the D-H and a significant effect of MR and [siRNA] on the zeta-potential of the nanocarriers."
For more information on this research see: Use of experimental design methodology for the development of new magnetic siRNA nanovectors (MSN). International Journal of Pharmaceutics, 2013;454(2):660-667. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
The news correspondents report that additional information may be obtained from S. David, Univ Tours, Fac Med, INSERM, Nutr Croissance & Canc U1069, F-37200 Tours, France. Additional authors for this research include H. Marchais, K. Herve-Aubert, D. Bedin, A.S. Garin, C. Hoinard and I. Chourpa (see also Small Interference RNAs (siRNAs)).
Keywords for this news article include: Tours, France, Europe, Genetics, Small Interference RNAs (siRNAs)
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