By a News Reporter-Staff News Editor at China Weekly News -- Researchers detail new data in Life Science Research. According to news reporting originating in San Francisco, California, by VerticalNews journalists, research stated, "Mice (Mus musculus) are the most commonly used laboratory animals. Viral metagenomics on tissues of immunodeficient mice revealed sequences of a novel mammalian astrovirus."
The news reporters obtained a quote from the research from Blood Systems Research Institute, "Using PCR, we screened mice from 4 breeders, 4 pharmaceutical companies, 14 research institutes and 30 universities in the US and Japan. Mice from one US breeder tested positive while none from Japanese breeders were positive for MuAstV. Mice in over half of the universities (19/30), institutes (7/14) and pharmaceutical animal facilities (2/4) investigated revealed the presence of MuAstV. Nine mice strains tested positive including both immunodeficient strains (NSG, NOD-SCID, NSG-3GS, C57BL6-Timp-3 (-/-), and uPA-NOG) and immunocompetent strains (B6J, ICR, Bash2, BALB/c). Our data indicates that MuAstV has a wide geographical, institutional and host strain distribution. Comparison of the MuAstV RdRp sequences showed numerous mutations indicating ongoing viral divergence in different facilities."
According to the news reporters, the research concluded: "This study demonstrates the need for metagenomic screening of laboratory animals to identify adventitious infections that may affect experimental outcomes."
For more information on this research see: Identification of an astrovirus commonly infecting laboratory mice in the US and Japan. Plos One, 2013;8(6):e66937. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news correspondents report that additional information may be obtained by contacting T.F. Ng, Blood Systems Research Institute, San Francisco, California, United States. Additional authors for this research include N.O. Kondov, N. Hayashimoto, R. Uchida, Y. Cha, A.I. Beyer, W. Wong, P.A. Pesavento, H. Suemizu, M.O. Muench and E. Delwart.
Keywords for this news article include: Asia, Japan, California, San Francisco, United States, Life Science Research, North and Central America.
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