By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Melanomas. According to news reporting from New Haven, Connecticut, by NewsRx journalists, research stated, "Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-tumor therapy. Our previous study demonstrated that cuprous oxide nanoparticles (CONPs) selectively induce apoptosis of tumor cells in vitro."
The news correspondents obtained a quote from the research from Yale University, "To explore the antitumor properties of CONPs in vivo, we used the particles to treat mouse subcutaneous melanoma and metastatic lung tumors, based on B16-F10 mouse melanoma cells, by intratumoral and systemic injections, respectively. The results showed that CONPs significantly reduced the growth of melanoma, inhibited the metastasis of B16-F10 cells and increased the survival rate of tumor-bearing mice. Importantly, the results also indicated that CONPs were rapidly cleared from the organs and that these particles exhibited little systemic toxicity. Furthermore, we observed that CONPs targeted the mitochondria, which resulted in the release of cytochrome C from the mitochondria and the activation of caspase-3 and caspase-9 after the CONPs entered the cells."
According to the news reporters, the research concluded: "CONPs can induce the apoptosis of cancer cells through a mitochondrion-mediated apoptosis pathway, which raises the possibility that CONPs could be used to cure melanoma and other cancers."
For more information on this research see: Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria. Cell Death & Disease, 2013;4():402-411. Cell Death & Disease can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group - www.nature.com/; Cell Death & Disease - www.nature.com/cddis/)
Our news journalists report that additional information may be obtained by contacting Y. Wang, Yale University, Sch Med, Dept. of Genet, New Haven, CT 06510, United States. Additional authors for this research include F. Yang, H.X. Zhang, X.Y. Zi, X.H. Pan, F. Chen, W.D. Luo, J.X. Li, H.Y. Zhu and Y.P. Hu (see also Melanomas).
Keywords for this news article include: New Haven, Apoptosis, Cytoplasm, Melanomas, Organelles, Connecticut, Mitochondria, Nanoparticle, United States, Nanotechnology, Cellular Structures, Intracellular Space, Emerging Technologies, Subcellular Fractions, North and Central America
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