By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Cardiology. According to news reporting originating in Beijing, People's Republic of China, by NewsRx journalists, research stated, "In this study, we investigated the cardiac biodistribution of polyethylene glycol (PEG)-coated AuNPs and their effects on cardiac function, structure and inflammation in both normal and cardiac remodeling mice. The model of cardiac remodeling was induced by subcutaneously injection of isoproterenol (ISO), a non-selective beta-adrenergic agonist, for 7 days."
The news reporters obtained a quote from the research from National Center for Nanoscience and Technology, "After AuNPs were injected intravenously in mice for 7 consecutive days, Au content in different organs was determined quantitatively by inductively coupled plasma mass spectrometry (ICP-MS), cardiac function and structure were measured by echocardiography, cardiac fibrosis was examined with picrosirius red staining, the morphology of cardiomyocytes was observed with hematoxylin and eosin (H & E) staining. The accumulation of AuNPs in hearts did not affect cardiac function or induce cardiac hypertrophy, cardiac fibrosis and cardiac inflammation under normal physiological condition. Cardiac AuNPs content was 6-fold higher in the cardiac remodeling mouse than normal mice. However, the increased accumulation of AuNPs in the heart did not aggravate ISO-induced cardiac hypertrophy, cardiac fibrosis or cardiac inflammation. These observations suggest that PEG-coated AuNPs possess excellent biocompatibility under both physiological and pathological conditions."
According to the news reporters, the research concluded: "Thus, AuNPs may be safe for cardiac patients and hold great promise for further development for various biomedical applications."
For more information on this research see: No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart. Toxicology Letters, 2013;222(2):197-203. Toxicology Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier - www.elsevier.com; Toxicology Letters - www.elsevier.com/wps/product/cws_home/505519)
Our news correspondents report that additional information may be obtained by contacting C.Z. Yang, Natl Center Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, People's Republic of China. Additional authors for this research include H. Yang, J.M. Wu, Z.H. Meng, R. Xing, A.J. Tian, X. Tian, L.J. Guo, Y.Y. Zhang, G.J. Nie and Z.J. Li (see also Cardiology).
Keywords for this news article include: Asia, Beijing, Cardiology, Inflammation, Nanotechnology, Gold Nanoparticles, Emerging Technologies, People's Republic of China
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