By a News Reporter-Staff News Editor at Information Technology Newsweekly -- Investigators publish new report on Bioinformatics. According to news reporting originating in Philadelphia, Pennsylvania, by VerticalNews journalists, research stated, "Knowledge of when and in which cells each gene is expressed across multicellular organisms is critical in understanding both gene function and regulation of cell type diversity. However, methods for measuring expression typically involve a trade-off between imaging-based methods, which give the precise location of a limited number of genes, and higher throughput methods such as RNA-seq, which include all genes, but are more limited in their resolution to apply to many tissues."
The news reporters obtained a quote from the research from the University of Pennsylvania, "We propose an intermediate method, which estimates expression in individual cells, based on high-throughput measurements of expression from multiple overlapping groups of cells. This approach has particular benefits in organisms such as C. elegans where invariant developmental patterns make it possible to define these overlapping populations of cells at single-cell resolution. We implement several methods to deconvolve the gene expression in individual cells from population-level data and determine the accuracy of these estimates on simulated data from the C. elegans embryo."
According to the news reporters, the research concluded: "These simulations suggest that a high-resolution map of expression in the C. elegans embryo may be possible with expression data from as few as 30 cell populations."
For more information on this research see: Deconvolution of gene expression from cell populations across the C. elegans lineage. Bmc Bioinformatics, 2013;14():204. (BioMed Central - www.biomedcentral.com/; Bmc Bioinformatics - www.biomedcentral.com/bmcbioinformatics/)
Our news correspondents report that additional information may be obtained by contacting J.T. Burdick, Genomics and Computational Biology Group, University of Pennsylvania, 440 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, United States.
Keywords for this news article include: Philadelphia, Pennsylvania, United States, Bioinformatics, North and Central America.
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