By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Cardiovascular Diseases and Conditions is the subject of a report. According to news reporting originating from Rochester, Minnesota, by NewsRx correspondents, research stated, "Cardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail to characterize CAV plaque morphology."
Our news editors obtained a quote from the research from the Mayo College of Medicine, "Our aim was to characterize CAV in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT). We prospectively enrolled 53 cardiac transplant patients to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and intravascular ultrasound (IVUS). The proximal 30 mm of the LAD was divided into three segments of 10 mm each (n 156). Segments with CAV plaque on IVUS were analysed by OCT for specific CAV morphological characteristics within the framework of three groups according to follow-up time after heart transplantation: (i) 03 months (n 18), (ii) 1236 months (n 55), and (iii) 48 months (n 83). The prevalence of atherosclerotic characteristics such as eccentric plaques, calcification, and lipid pools increased from 6, 0, and 6 in group 1 to 78, 42, and 61 in group 3, respectively (all P 0.001). The prevalence of vulnerable plaque features such as thin-cap fibroatheroma, macrophages, and microchannels increased from 0 in group 1 to 12, 29, and 33 in group 3, respectively (P 0.19, P 0.006, and P 0.003). Complicated coronary lesions such as intimal laceration, intraluminal thrombus, and layered complex plaque increased from 0 in group 1 to 18, 19, and 57 in group 3 (P 0.009, P 0.001, and P 0.001). Plaque rupture was identified in 4 of group 3 segments."
According to the news editors, the research concluded: "The current study gives new insight into CAV that extends far beyond the current concept of concentric and fibrosing vasculopathy, that is, the development of atherosclerosis with vulnerable plaque and complicated coronary lesions."
For more information on this research see: Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: new insight into cardiac allograft vasculopathy by optical coherence tomography. European Heart Journal, 2013;34(33):2610-2617. European Heart Journal can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; European Heart Journal - eurheartj.oxfordjournals.org)
The news editors report that additional information may be obtained by contacting A. Cassar, Mayo College of Medicine, Div Nephrol & Hypertens, Rochester, MN 55905, United States. Additional authors for this research include Y. Matsuo, J. Herrmann, J. Li, R.J. Lennon, R. Gulati, L.O. Lerman, S.S. Kushwaha and A. Lerman (see also Cardiovascular Diseases and Conditions).
Keywords for this news article include: Rochester, Minnesota, Cardiology, United States, Atherosclerosis, Arteriosclerosis, Imaging Technology, Allograft Vasculopathy, North and Central America, Arterial Occlusive Diseases, Optical Coherence Tomography, Cardiovascular Diseases and Conditions
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