By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Neurons have been published. According to news reporting originating in Homburg, Germany, by NewsRx journalists, research stated, "Beside the promising application potential of nanotechnologies in engineering, the use of nanomaterials in medicine is growing. New therapies employing innovative nanocarrier systems to increase specificity and efficacy of drug delivery schemes are already in clinical trials."
The news reporters obtained a quote from the research from the University of Saarland, "However the influence of the nanoparticles themselves is still unknown in medical applications, especially for complex interactions in neural systems. The aim of this study was to investigate in vitro effects of coated silver nanoparticles (cAgNP) on the excitability of single neuronal cells and to integrate those findings into an in silico model to predict possible effects on neuronal circuits. We first performed patch clamp measurements to investigate the effects of nanosized silver particles, surrounded by an organic coating, on excitability of single cells. We then determined which parameters were altered by exposure to those nanoparticles using the Hodgkin-Huxley model of the sodium current. As a third step, we integrated those findings into a well-defined neuronal circuit of thalamocortical interactions to predict possible changes in network signaling due to the applied cAgNP, in silico. We observed rapid suppression of sodium currents after exposure to cAgNP in our in vitro recordings. In numerical simulations of sodium currents we identified the parameters likely affected by cAgNP. We then examined the effects of such changes on the activity of networks. In silico network modeling indicated effects of local cAgNP application on firing patterns in all neurons in the circuit. Our sodium current simulation shows that suppression of sodium currents by cAgNP results primarily by a reduction in the amplitude of the current."
According to the news reporters, the research concluded: "The network simulation shows that locally cAgNP-induced changes result in changes in network activity in the entire network, indicating that local application of cAgNP may influence the activity throughout the network."
For more information on this research see: Estimating the modulatory effects of nanoparticles on neuronal circuits using computational upscaling. International Journal of Nanomedicine, 2013;8():3559-3572. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Neurons).
Our news correspondents report that additional information may be obtained by contacting M. Busse, University of Saarland, Fac Med, Dept. of Physiol, D-66421 Homburg, Germany. Additional authors for this research include D. Stevens, A. Kraegeloh, C. Cavelius, M. Vukelic, E. Arzt and D.J. Strauss.
Keywords for this news article include: Cells, Europe, Homburg, Germany, Neurons, Nanoparticle, Nanotechnology, Emerging Technologies, Clinical Trials and Studies
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