By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Nanoparticles are presented in a new report. According to news reporting originating from Zaragoza, Spain, by NewsRx correspondents, research stated, "Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and long-term toxicity in the body. Dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles have been proven efficient for in vivo drug delivery, but these results must nonetheless be sustained by comprehensive studies of long-term distribution, degradation and toxicity."
Our news editors obtained a quote from the research from the University of Zaragoza, "We studied DMSA-coated magnetic nanoparticle effects in vitro on NCTC 1469 non-parenchymal hepatocytes, and analyzed their biodistribution and biotransformation in vivo in C57BL/6 mice. Our results indicate that DMSA-coated magnetic nanoparticles have little effect on cell viability, oxidative stress, cell cycle or apoptosis on NCTC 1469 cells in vitro. In vivo distribution and transformation were studied by alternating current magnetic susceptibility measurements, a technique that permits distinction of MNP from other iron species. Our results show that DMSA-coated MNP accumulate in spleen, liver and lung tissues for extended periods of time, in which nanoparticles undergo a process of conversion from superparamagnetic iron oxide nanoparticles to other non-superparamagnetic iron forms, with no significant signs of toxicity."
According to the news editors, the research concluded: "This work provides the first evidence of DMSA-coated magnetite nanoparticle biotransformation in vivo."
For more information on this research see: Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications. Journal of Controlled Release, 2013;171(2):225-233. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news editors report that additional information may be obtained by contacting R. Mejias, University of Zaragoza, Dept. of Mat & Fluids Sci & Technol, Zaragoza 50018, Spain. Additional authors for this research include L. Gutierrez, G. Salas, S. Perez-Yague, T.M. Zotes, F.J. Lazaro, M.P. Morales and D.F. Barber (see also Nanoparticles).
Keywords for this news article include: Spain, Europe, Zaragoza, Nanotechnology, Emerging Technologies, Magnetic Nanoparticles
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