By a News Reporter-Staff News Editor at TB & Outbreaks Week -- Current study results on Gram-Negative Bacteria have been published. According to news originating from Caracas, Venezuela, by NewsRx correspondents, research stated, "Helicobacter pylori is a major cause of chronic gastritis and an established risk factor for gastric adenocarcinoma. This bacterium also exhibits an extraordinarily high genetic diversity."
Our news journalists obtained a quote from the research from Center for Biotechnology, "The genetic diversity of H. pylori strains from Venezuelan patients with chronic gastritis was evaluated by PCR-typing of vacA, cagA, iceA, and babA2 virulence-associated genes using DNA extracted directly from biopsies. The nucleotide sequence and prevalence of size variants of iceA1, iceA2, and babA2 PCR products were introduced in this analysis. The frequency of vacA s1 was associated (p < 0.01) with moderate/severe grades of atrophic gastritis. The cagA, iceA1, iceA2, and babA2 genotypes were found in 70.6%, 66.4%, 33.6%, and 92.3% of strains, respectively. The frequency of iceA2 and its subtype iceA2_D were higher (p < 0.015) in cases with moderate/severe granulocytic inflammation. The most prevalent combined genotypes were vacA s1m1/cagA/iceA1/babA2 (26.3%), vacA s2m2/iceA1/babA2 (19.5%), and vacA s1m1/cagA/iceA2/babA2 (18.8%). Sequence analysis of iceA1, iceA2, and babA2 PCR-amplified fragments allowed us to define allelic variants and to increase the number of genotypes detected (from 19 to 62). A phylogenetic tree made with iceA1 sequences showed that the H. pylori strains analyzed here were grouped with those of Western origin. Our results show that patients from the western region of Venezuela have an elevated prevalence of infection with H. pylori strains carrying known virulence genotypes with high genetic diversity."
According to the news editors, the research concluded: "This highlights the importance of identifying gene variants for an early detection of virulent genotypes."
For more information on this research see: Genotyping of Helicobacter pylori virulence-associated genes shows high diversity of strains infecting patients in western Venezuela. International Journal of Infectious Diseases, 2013;17(9):E750-E756. International Journal of Infectious Diseases can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; International Journal of Infectious Diseases - www.elsevier.com/wps/product/cws_home/701730)
The news correspondents report that additional information may be obtained from M.A. Chiurillo, Inst Estudios Avanzados, Center Biotecnol, Caracas, Venezuela. Additional authors for this research include Y. Moran, M. Canas, E. Valderrama, N. Granda, M. Sayegh and J.L. Ramirez (see also Gram-Negative Bacteria).
Keywords for this news article include: Caracas, Venezuela, South America, Helicobacter pylori, Epsilonproteobacteria, Gram-Negative Bacteria
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