By a News Reporter-Staff News Editor at Biotech Business Week -- Researchers detail new data in Oncology. According to news originating from Houston, Texas, by NewsRx correspondents, research stated, "There is evidence that exposure to chlorinated solvents may be associated with childhood medulloblastoma and primitive neuroectodermal tumor (M/PNET) risk. Animal models suggest genes related to detoxification and DNA repair are important in the carcinogenicity of these pollutants; however, there have been no human studies assessing the modifying effects of these genotypes on the association between chlorinated solvents and childhood M/PNET risk."
Our news journalists obtained a quote from the research from the University of Texas, "We conducted a case-only study to evaluate census tract-level exposure to chlorinated solvents and the risk of childhood M/PNET in the context of detoxification and DNA repair genotypes. Cases (n=98) were obtained from Texas Children's Hospital and MD Anderson Cancer Center. Key genotypes (n=22) were selected from the Illumina Human 1M Quad SNP Chip. Exposure to chlorinated solvents (methylene chloride, perchloroethylene, trichloroethylene, and vinyl chloride) was estimated from the US EPA's 1999 Assessment System for Population Exposure Nationwide (ASPEN). Logistic regression was used to estimate the case-only odds ratios and 95% confidence intervals (CIs). There were 11 significant gene-environment interactions associated with childhood M/PNET risk. However, after correcting for multiple comparisons, only the interaction between high trichloroethylene levels and OGG1 rs293795 significantly increased the risk of childhood M/PNET risk (OR=9.24, 95% CI: 2.24, 38.24, Q=0.04). This study provides an initial assessment of the interaction between ambient levels of chlorinated solvents and potentially relevant genotypes on childhood M/PNET risk."
According to the news editors, the research concluded: "Our results are exploratory and must be validated in animal models, as well as additional human studies."
For more information on this research see: An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. Pediatric Blood & Cancer, 2012;59(4):605-10. (Wiley-Blackwell - www.wiley.com/; Pediatric Blood & Cancer - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1545-5017)
The news correspondents report that additional information may be obtained from P.J. Lupo, Human Genetics Center, Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, United States. Additional authors for this research include L.J. Lee, M.F. Okcu, M.L. Bondy and M.E Scheurer (see also Oncology).
Keywords for this news article include: Texas, Houston, Genetics, Oncology, Pediatrics, United States, Medulloblastoma, North and Central America.
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