The study utilized non-obese laboratory mice that spontaneously develop autoimmune insulin dependent diabetes.
Results of the study demonstrate that treatment with CGEN-15001 prevented development of diabetes throughout the 4 months of follow-up. Animals treated with CGEN-15001 maintained normal blood glucose levels compared with untreated animals that developed high blood glucose. The sustained duration of response following a short-term treatment with CGEN-15001, also observed previously in other disease models of autoimmunity, suggests that CGEN-15001 turns off the autoimmune process and may potentially lead to restoration of immune tolerance and resolution of autoimmunity, thereby arresting disease progression.
"We have already shown through various preclinical studies that CGEN-15001 has the potential to serve as an efficacious disease modifying therapy for multiple sclerosis and rheumatoid arthritis," said
Immune checkpoints are inhibitory receptors, which are crucial for the maintenance of self-tolerance (that is, the prevention of autoimmunity) and for the protection of tissues from damage when the immune system is performing its intended function of responding to pathogenic infection. Autoimmune diseases, such as type I diabetes, multiple sclerosis and rheumatoid arthritis, are mediated by self-reactive T cells that have escaped immune tolerance to self-proteins.
Keywords for this news article include: Diabetes, Treatment, Immunotherapy, Immunomodulation.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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