"Spatial heterogeneity of cancer genomes has been shown for multiple tumor types, which adds complexity to the genomic data collected from any given tumor biopsy because it is potentially unrepresentative of the tumor as a whole," explained Dr.
In this study, the Adaptive and the Fred Hutch team examined five large primary and metastatic ovarian tumors to determine whether the same population of Tumor Infiltrating Lymphocytes (TILs) was uniformly present throughout the tumors, or whether different tumor sections contained different populations of infiltrating T-cells. Using high-throughput sequencing provided by the immunoSEQ platform, the team identified the specific T-cell lineages present in up to 22 different biopsies from each tumor. The study demonstrated that the T-cells infiltrating these five ovarian tumors were homogenous, with largely the same T-cells observed regardless of the biopsy examined.
These data also complement a global effort under way to validate the need to incorporate a measure of immune-fighting T-cells, or TILs, into the staging criteria for patients with solid tumors. Adaptive and many research-based institutions globally are generating data demonstrating that patients with a "stronger" immune response to their tumor have a statistically higher chance of survival, often irrespective of tumor size or treatment protocol.
"The implication of this study on the field of oncology and diagnostics is profound," remarked CEO and co-founder,
Funding for this study was provided by the
Adaptive is also applying immune profiling to the burgeoning cancer immunotherapy field, measuring properties of the host response to the tumor to both predict response to and monitor adverse events from immunotherapy drugs. The Company executed a biomarker discovery deal with
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Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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