BERLIN, Oct. 16, 2013 (GLOBE NEWSWIRE) -- Given Imaging (Nasdaq:GIVN), a world leader in specialty GI products and pioneer of capsule endoscopy, today announced numerous studies confirming the value of its reflux and manometry products in diagnosing, monitoring and managing a range of gastrointestinal diseases. The studies were presented at United European Gastroenterology Week (UEG Week), taking place from October 12-16, 2013 at the Internationales Congress Centrum Berlin where Given Imaging is exhibiting at Hall 15.1, Booth #7 throughout the conference. Results of more than 110 clinical studies of Given Imaging's products were presented at UEG Week this year demonstrating the breadth and utility of its portfolio.
"New tools like high-resolution manometry and prolonged pH monitoring deliver more detailed and more relevant information that allow us to explain the causes of patient symptoms and to better manage patients with esophageal disorders," said Mark Fox, M.D., Division of Gastroenterology of University Hospital Zurich. "It is important that we continue to use these tools to select the most appropriate pharmacologic as well as surgical therapies."
Key Given Imaging highlights include the following studies at UEG Week:
pH and pH-Impedance Monitoring
•"Understanding the Cause of Persistent GERD Symptoms Despite Proton Pump Inhibitor Therapy: Impedance-pH Monitoring Revisited"(poster 460):Daphne Ang M.D., Changi General Hospital, Department of Gastroenterology, Singapore, presented data on use of impedance-pH testing showing that both acid reflux and non-acid reflux events account for persistent symptoms in PPI (proton pump inhibitors) non-responders, especially patients with typical reflux symptoms. Authors noted that therapies beyond PPI may be necessary.
•"The Real Prevalence of Functional Heartburn: The Lesson of Prolonged Wireless pH Monitoring" (poster 1598): Roberto Penagini M.D. of the Cattedra di Gastroenterologia, UniversitÀ degli Studi and Fondazione IRCCS, Ospedale Maggiore, Mangiagalli e Regina Elena, Milan, Italy, presented a study showing how use of either a 48-hr catheter or 48 to 96-hr wireless study can provide a more accurate diagnosis of functional heartburn than standard of care. Functional heartburn is diagnosed in patients with heartburn refractory to PPIs when endoscopy, esophageal acid exposure time (AET), and symptom index (SI) are negative. Diagnosing functional heartburn is important as it often leads to a change in the way patients are managed.
•"Assessment of Patients Referred for GERD Evaluation: To Continue or Stop Acid Suppressants Before Functional Tests?" (oral presentation 379): Presenter Daphne Ang M.D., of Changi General Hospital, Department of Gastroenterology, Singapore, showed data from a study involving 2925 patients that aimed to determine the diagnostic yield of functional studies performed on and off proton pump inhibitor (PPI) therapy. Investigators concluded that among those GERD patients with insufficient treatment response, improved diagnostic yield was achieved with multichannel intraluminal impedance-wireless pH monitoring performed on PPI therapy for evaluation of non-acid reflux and off therapy for acid reflux evaluation.
•"Esophageal Work-Up Prior to Bariatric Surgery: Who and How to Investigate?" (poster 1599): Benjamin Heimgartner, M.D., Inselspital, Bern University Hospital, Gastroenterology and Hepatology, Bern, Switzerland, presented data from this study that examined the optimal diagnostic work-up in an obese patient population. Results showed that reflux monitoring is superior to endoscopy in detecting GERD, yet a substantial number of patients with erosive esophagitis had "normal" esophageal acid exposure. Since typical reflux symptoms do not predict the presence of esophagitis and abnormal acid exposure, the study investigators recommend including endoscopy and reflux monitoring as part of the pre-operative work-up prior to bariatric surgery.